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The ACCP also recognizes oscillatory devices, such as the flutter and high-frequency chest wall oscillation, as effective at enhancing mucus clearance

Since UA-lowering therapies induce sustainable reduction in UA levels, it was expected that interventional studies in analogy with the Mendelian randomization studies, will help in clarification of the causal relationship between UA and CVD

Despite all the advancements, the fundamental question remains regarding the underlying mechanism that gives rise to various effects differed by ApoE genotypes